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. Author manuscript; available in PMC: 2010 May 14.
Published in final edited form as: J Phys Chem B. 2009 May 14;113(19):6692–6702. doi: 10.1021/jp9016773

Fig. 6.

Fig. 6

(a) Two-dimensional projections of the free energy ΔF(H,S) as a function of the helix and strand fractions, H and S: Aβ1–40 monomer (left panel); Aβ10–40 monomer (right panel). The minima in free energy are set to zero. The values of ΔF(H, S) are color coded according to the scale. (b) One-dimensional profiles of the free energy ΔF(S): Aβ1–40 monomers (squares); Aβ10–40 monomers (circles). The states with zero strand contents are set to have zero free energy. The plots in (a) and (b) demonstrate that β-strand structure is stabilized in Aβ1–40 compared to Aβ10–40. ΔΔFS is the free energy difference between the β-strand states in Aβ1–40 and Aβ10–40. β-strand states are operationally defined to have free energies less than −2RT.