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. 2010 Feb 19;10:52. doi: 10.1186/1471-2148-10-52

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Copyright ©2010 Sawai et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lineage-specific positive selection in the phylogeny of msp1 from P. vivax and P. vivax-related simian malaria parasite species. The maximum-likelihood (ML) tree topology was constructed using sequences of msp1 codon 3 for (a) the whole msp1 gene, (b) the 5' region, (c) the central region and (d) the 3' region. The estimates of kA and kS (×100) are shown above each branch. Branches showing ω (= kA/kS) >1 are bold-lined. A branch showing ω significantly greater than 1 (P < 0.05), when the free ratio model was compared with the constrained model that fixed ω of the branch of interest at 1, is double-asterisked; and that weakly higher than 1 (P < 0.1) is asterisked. Abbreviations are: Pfi, P. fieldi N-3; Pvi, P. vivax Sal-I; Pcy, P. cynomolgi Smithsonian; Phy, P. hylobati; Pin, P. inui Celebes; Pco, P. coatneyi; Pkn, P. knowlesi H; Pfr, P. fragile NIH; Pgo, P. gonderi.