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. Author manuscript; available in PMC: 2011 Mar 30.
Published in final edited form as: J Neurosci Methods. 2010 Jan 21;187(2):207–215. doi: 10.1016/j.jneumeth.2010.01.012

Fig 5.

Fig 5

Effect of masticatory muscle inflammation on gnaw time. CFA was injected bilaterally into the masseter muscle of mice and their gnaw time was compared to control saline-injected mice and indomethacin-pretreated mice receiving CFA injection into the masseter muscle. Gnaw time was significantly increased 10 hours post-CFA injection (white circles, n=4) compared to saline injection (black squares, n=4) into the masseter muscles (*P<0.05, Mann-Whitney U Test). Indomethacin pretreatment (5mg/kg intraperitoneal) 30 minutes prior to CFA injection (black circles, n=5) into the masseter muscles completely blocked CFA effects on gnaw time increase (*P<0.05, Mann-Whitney U Test).