Table 2.

lists specific autoantibodies with their antigenic determinant and clinical disease associations.

Autoantibody	Antigenic Determinant	Clinical Associations
Anti-dsDNA	Double stranded-DNA	High specificity for SLE
		Often correlates with active, severe disease
Anti-Extractable
Nuclear Antigens
Anti-Sm	Smith	High specificity for SLE
Anti-RNP	proteins containing U1-RNA	MCTD, SLE, RA, Scleroderma, Sjögren's
Anti-SSA (Ro)	Ribonucleoproteins	Sjögren's syndrome, SLE (subacute cutaneous lupus), neonatal lupus
Anti-SSB (La)	Ribonucleoproteins	Sjögren's syndrome, SLE, neonatal SLE
Anti-centromere	Centromere/kinetochore region of chromosome	Limited scleroderma, pulmonary hypertension, primary biliary cirrhosis
Anti-Scl 70	DNA topoisomerase I	Diffuse scleroderma
Anti-Jo-1 (anti-synthetase Abs)	Histidyl tRNA synthetase (other tRNA synthetases)	Inflammatory myopathies with interstitial lung disease, fever and arthritis
Anti-SRP	Antibody to signal recognition protein	Inflammatory myopathies with poor prognosis
Anti-PM/Scl	Antibody to nucleolar granular component	Polymyositis/scleroderma overlap syndrome
Anti-Mi-2	Antibodies to a nucleolar antigen of unknown function	Dermatomyositis

MCTD = mixed connective tissue disease