Table 2.
Autoantibody | Antigenic Determinant | Clinical Associations |
---|---|---|
Anti-dsDNA | Double stranded-DNA | High specificity for SLE |
Often correlates with active, severe disease | ||
Anti-Extractable | ||
Nuclear Antigens | ||
Anti-Sm | Smith | High specificity for SLE |
Anti-RNP | proteins containing U1-RNA | MCTD, SLE, RA, Scleroderma, Sjögren's |
Anti-SSA (Ro) | Ribonucleoproteins | Sjögren's syndrome, SLE (subacute cutaneous lupus), neonatal lupus |
Anti-SSB (La) | Ribonucleoproteins | Sjögren's syndrome, SLE, neonatal SLE |
Anti-centromere | Centromere/kinetochore region of chromosome | Limited scleroderma, pulmonary hypertension, primary biliary cirrhosis |
Anti-Scl 70 | DNA topoisomerase I | Diffuse scleroderma |
Anti-Jo-1 (anti-synthetase Abs) | Histidyl tRNA synthetase (other tRNA synthetases) | Inflammatory myopathies with interstitial lung disease, fever and arthritis |
Anti-SRP | Antibody to signal recognition protein | Inflammatory myopathies with poor prognosis |
Anti-PM/Scl | Antibody to nucleolar granular component | Polymyositis/scleroderma overlap syndrome |
Anti-Mi-2 | Antibodies to a nucleolar antigen of unknown function | Dermatomyositis |
MCTD = mixed connective tissue disease