Table 2.

Rate of disease progression in patients with all LRRK2 mutations and LRRK2 Gly2019Ser

	Time of progression to H and Y stage		Proportion of patients at each H and Y stage with PD for 10 years or longer
	All mutations (n=321)	Gly2019Ser (n=291)	All mutations (n= 257)	Gly2019Ser (n=226)
H and Y stage 1	4·0 years	4·1 years	6%	6%
H and Y stage 2	7·2 years	7·4 years	27%	31%
H and Y stage 3	9·4 years	9·1 years	45%	44%
H and Y stage 4	12·6 years	12·9 years	57%	61%
H and Y stage 5	15·6 years	16·2 years	79%	82%

Average number of years it took each patient to reach each stage of the H and Y scale and the percentage of patients at each stage who had symptoms for 10 years or longer. H and Y=Hoehn and Yahr scale