Table 2.
Effect of Ocimum sanctum and its saponin rich fraction on thio-barbituric acid reactive substances, superoxide anion content and total calcium in vincristine-induced neuropathic pain.
| Groups | Doses | Total Protein (mg/g of tissue) |
TBARS (nmol/mg of protein) |
Superoxide Anion Content (pmol/min/mg of protein) |
Total Calcium (ppm/mg of protein) |
|---|---|---|---|---|---|
| Normal Control | - | 5.17 ± 0.23 | 5.97 ± 0.26 | 0.15 ± 0.02 | 4.97 ± 0.21 |
| Vincristine Control | - | 5.36 ± 0.13 | 8.28 ± 0.24a | 0.79 ± 0.05a | 32.20 ± 0.18a |
| Vehicle in Vincristine Control | - | 5.29 ± 0.17 | 8.24 ± 0.22a | 0.81 ± 0.03a | 32.02 ± 0.16 a |
| Ocimum sanctum per se | 200 mg/kg | 5.21 ± 0.15 | 6.00 ± 0.28 | 0.16 ± 0.01 | 5.09 ± 0.15 |
| Saponin rich fraction per se | 200 mg/kg | 5.30 ± 0.14 | 6.06 ± 0.24 | 0.14 ± 0.02 | 4.92 ± 0.17 |
| Ocimum sanctum in vincristine control | 100 mg/kg | 5.33 ± 0.22 | 7.56 ± 0.16a, b | 0.56 ± 0.02a, b | 29.5 ± 0.18a, b |
| Ocimum sanctum in vincristine control | 200 mg/kg | 5.26 ± 0.16 | 7.52 ± 0.15a, b | 0.54 ± 0.03a, b | 29.8 ± 0.20a, b |
| Saponin rich fraction in vincristine control | 100 mg/kg | 5.35 ± 0.13 | 6.90 ± 0.19a, b, c | 0.38 ± 0.04a, b, c | 21.1 ± 0.19a, b, c |
| Saponin rich fraction in vincristine control | 200 mg/kg | 5.29 ± 0.14 | 6.28 ± 0.21a, b, c, d | 0.25 ± 0.02a, b, c, d | 12.2 ± 0.13a, b, c, d |
Data were expressed as mean ± S.E.M., n = 6 rats per group a = p < 0.05 Vs normal control group, b = p < 0.05 Vs vincristine control group, c = p < 0.05 Vs Ocimum sanctum100 and 200 mg/kg group, d = p < 0.05 Vs saponin rich fraction 100 mg/kg group.