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. 2009 Nov 30;115(9):1835–1842. doi: 10.1182/blood-2009-03-211706

Figure 1.

Figure 1

TACEΔZn/ΔZn platelets are protected from storage-induced shedding of GPIb-α and increased posttransfusion clearance. (A) Surface expression of GPIb-α was determined by flow cytometry on freshly isolated or 15-hour stored platelet-rich plasma (PRP) from TACE+/+ and TACEΔZn/ΔZn mice. Results are mean ± SEM; n = 6. n.s. indicates not significant. (B) Platelets from stored PRP from TACE+/+ and TACEΔZn/ΔZn mice were washed in Tyrode-N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid buffer and labeled with CFSE. A total of 108 platelets/10 g of body weight was infused intravenously into TACE+/+ mice. Blood was drawn at the indicated time points, and platelets were immediately analyzed by flow cytometry. Results are mean percentage CFSE-labeled platelets ± SEM; n = 4. ***P < .001. *P < .05.