Table 3.
Top genes in CSSCD identified by SSEA
| Official gene name | Location | CSSCD (n = 848) |
Replication set (n = 305) |
Thai (n = 152) |
Hong Kong (n = 406) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of SNPs in gene | Significant SNPs | SSEA P | No. of SNPs in gene | Significant SNPs | SSEA P | No. of SNPs in gene | Significant SNPs | SSEA P | No. of SNPs in gene | Significant SNPs | SSEA P | ||
| OR51B6 | 11p15.4 | 14 | 10 | 1.86E−15 | 9 | 8 | 7.57E−09 | 10 | 0 | .44 | 11 | 0 | .42 |
| OR51B5 | 11p15.4 | 16 | 9 | 1.19E−12 | 9 | 7 | 3.79E−07 | 9 | 0 | .47 | 12 | 1 | .38 |
| BCL11A | 2p16.1 | 31 | 8 | 3.68E−08 | 13 | 6 | 1.66E−04 | 9 | 6 | 1.67E−05 | 16 | 7 | 8.41E−05 |
| OR51B2 | 11p15 | 10 | 5 | 3.27E−07 | 3 | 1 | .19 | 5 | 3 | .004 | 13 | 0 | .36 |
Genes enriched with significant SNPs in CSSCD with SSEA (P < .001) and replicated in at least one of the replication sets. The number of significant SNPs is the number of SNPs with individual P value less than .01 in CSSCD and .05 in the replication (Thailand and Hong Kong sets).