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. Author manuscript; available in PMC: 2010 Mar 5.
Published in final edited form as: Arch Biochem Biophys. 2009 Feb 21;485(2):139–149. doi: 10.1016/j.abb.2009.02.008

Figure 8. Proposed scheme for function of cytosolic Prdx6.

Figure 8

1) Prdx6 is a cytosolic protein in the normal resting cell. 2) With oxidant stress (indicated by H2O2), oxidation of membrane phospholipids leads to an increased Prdx6 accessibility to substrate related to increased hydrophilicity of the phospholipid hydroperoxide. 3) Binding of Prdx6 to the membrane results in glutathione (GSH) – mediated reduction of the oxidized substrate, restoring membrane integrity and 4) leading to release of Prdx6 from binding to the now-reduced phospholipid.