Table 1.
—Baseline Donor and Recipient Characteristics and Recipient Pulmonary Disease Causes
| Characteristics | LLAS | ILAS | P Value | HLAS | P Value |
| No.a | 3161 | 411 | 197 | ||
| Age, recipient (IQR) | 51.81 (17) | 52.18 (16) | .6143 | 51.64 (20) | .877 |
| BMI, recipient (IQR) | 24.46 (7.52) | 24.59 (8.09) | .6063 | 25.17 (7.07) | .0483 |
| Diabetes mellitus, recipient (%) | 503 (15.91) | 103 (25.06) | < .001 | 50 (25.38) | < .001 |
| eGRF, recipient (IQR) | 58.59 (6.33) | 58.26 (7.29) | .3301 | 55.96 (12.33) | < .001 |
| Glucocorticoids, recipient (%) | 1479 (46.79) | 230 (55.96) | < .001 | 123 (62.44) | < .001 |
| Infection, recipient (%) | 286 (9.04) | 72 (17.52) | < .001 | 55 (27.92) | < .001 |
| Peripheral vascular disease, recipient (%) | 20 (0.63) | 4 (0.97) | .427 | 2 (1.02) | .519 |
| Double lung transplants (%) | 1,923 (60.84) | 271 (65.94) | .046 | 140 (71.07) | .004 |
| One previous lung transplant (%) | 116 (3.67) | 33 (8.03) | < .001 | 27 (13.71) | < .001 |
| Two previous lung transplants (%) | 3 (0.09) | 1 (0.24) | .387 | 2 (1.02) | .0304 |
| Hospitalized at time of transplant (%) | 329 (10.41) | 124 (30.17) | < .001 | 137 (69.54) | < .001 |
| Hospitalized in ICU at time of transplant (%) | 140 (4.43) | 70 (17.03) | < .001 | 102 (51.78) | < .001 |
| Intubated at time of transplant (%) | 62 (1.96) | 40 (9.73) | < .001 | 71 (36.04) | < .001 |
| On ECMO at time of transplant (%) | 11 (0.35) | 3 (0.73) | .244 | 10 (5.08) | < .001 |
| Cause of death | |||||
| Cystic fibrosis (%) | 463 (14.65) | 47 (11.44) | .080 | 19 (9.64) | .052 |
| COPD (%) | 1,090 (34.48) | 23 (5.60) | < .001 | 13 (6.60) | < .001 |
| Pulmonary fibrosis (%) | 899 (28.44) | 234 (56.93) | < .001 | 112 (56.85) | < .001 |
| Sarcoidosis (%) | 114 (3.61) | 17 (4.14) | .591 | 7 (3.55) | .969 |
| Reoperative lung transplant (%) | 98 (3.10) | 28 (6.81) | < .001 | 25 (12.69) | < .001 |
| Other (%) | 57 (1.80) | 15 (3.65) | .0122 | 3 (1.52) | .773 |
| Age, donor (IQR) | 33.15 (26) | 32.11 (24) | .1773 | 34.97 (25) | .0908 |
| Ischemic time (IQR) | 4.98 (2.08) | 5.13 (2.03) | .0807 | 5.24 (2.08) | .040 |
| Pulmonary infection, donor (%) | 852 (26.95) | 106 (25.79) | .617 | 55 (27.92) | .767 |
| Insulin-dependent diabetes mellitus, donor (%) | 64 (2.03) | 4 (0.98) | .142 | 7 (3.55) | .148 |
P values were calculated using patients with an LLAS as the reference group. ECMO = extracorporeal membrane oxygenation; eGFR = estimated glomerular filtration rate; HLAS = high lung allocation score; ILAS = intermediate lung allocation score; IQR = interquartile range; LLAS = low lung allocation score.
a
Total number of participants, both donors and recipients, was 3,769.