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Effect of 21 (A) and 32 (C) (both dosed at 200 mg/kg po 5 days per week) on the growth of U87MG human glioblastoma xenografts in CrTac:Ncr-Fox1(nu) athymic mice. Effect of 21 (B) and 32 (D) on PKB phosphorylation of GSK3β in U87MG human tumor xenografts at 4 h (B) or 6 h (D) following a single dose of 200 mg/kg po.
