Table 3. 4-Azaindole, 8-Oxopurine, and Pyrazolo[3,4-b]pyridine Hinge Binders Substituted with Selected 4-Aminopiperidines.

^aInhibition of PKBβ kinase activity in a radiometric filter binding assay,(17) single determination. Standard inhibitor N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide (H-89) gave mean IC₅₀ (±SD) = 590 (±220) nM (n = 20).

^bMean of two determinations, individual values in parentheses.

^cnd = not determined.