Table 4. Cellular Activities of Selected Compounds in PC3M (Prostate) and U87MG (Glioblastoma) Human Tumour Cell Lines^a.

	PC3M		U87MG
no.	SRB GI50 (μM)b	ELISA IC50 (μM)c	SRB GI50 (μM)d	ELISA IC50 (μM)e
2	12	3.0	5.0	0.66
10	8.9 (7.7, 10)f	4.0	5.7	ndg
12	8.5 (8.0, 8.9)f	1.9	5.9	ndg
14	20	6.7	14	ndg
19	ndg	ndg	5.1	0.59
21	>50h	2.3 (2.3, 2.3)f	17	0.93
28	26	3.8	17	ndg
32	ndg	ndg	20	2.8
33	29	4.2	34	ndg
36	9.3	0.37 (0.36, 0.37)f	4.6	ndg
37	ndg	ndg	3.7	3.2
38	ndg	ndg	19	7.2
40	ndg	ndg	13	8.8
41	ndg	ndg	>50	>50
42	ndg	ndg	16	2.7
43	ndg	ndg	7.0	6.5

^aInhibition of PKBβ kinase activity in a radiometric filter binding assay,(17) single determination. Standard inhibitor N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide (H-89) gave mean IC₅₀ (±SD) = 590 (±220) nM (n = 20).

^bCell growth inhibition by sulforhodamine B colorimetric assay,(33) single determination in PC3 M human prostate cancer cells. Standard inhibitor H-89 gave mean (±SD) IC₅₀ = 18 (±6.0) μM in this assay.

^cCellular ELISA for inhibition of GSK3β phosphorylation in PC3 M cells,(32) Standard inhibitor H-89 gave mean (±SD) IC₅₀ = 15 (±2.0) μM.

^dCell growth inhibition by sulforhodamine B colorimetric assay,(32) single determination in U87MG human glioblastoma cancer cells. Standard inhibitor H-89 gave mean (±SD) IC₅₀ = 15 (±2.3) μM in this assay.

^eCellular ELISA for inhibition of GSK3β phosphorylation in U87MG cells.(32) Standard inhibitor 2-(4-morpholino)-8-phenyl-4H-1-benzopyran-4-one (LY294002) gave IC₅₀ = 8.1 (±3.0) μM.

^fMean of n = 2 determinations, individual values in parentheses.

^gnd not determined.

^hn = 2 determinations.