Fig. 5.

Systolic blood pressure and proteinuria/creatinine ratio in congenic rat substrains for α- and β-adducin. Indirect systolic blood pressure (left) and urinary protein excretion normalized for creatinine excretion (right) were measured in male parental hypertensive MHS and normotensive MNS rats and in congenic substrains obtained by introgressing α-adducin (NA), β-adducin (NB), and αβ-adducin (NAB) from MHS into the MNS genetic background. The measurements have been done in rats at 3 (left) and 6 (right) months of age. Data are mean ± SEM. Rat numbers are indicated in the bars. No variation of heart rate was observed in any congenic substrain as compared to MNS (not shown). *p < 0.05, **p < 0.01, ***p < 0.001 vs. MNS; $$p < 0.01 vs. NB