Fig. 6.

Glomerular morphologic analysis in kidneys from congenic rat substrains for α- and β-adducin. Histomorphological studies have been conducted in kidney preparations from male parental hypertensive MHS and normotensive MNS rats and in congenic substrains for α-adducin (NA), β-adducin (NB), and αβ-adducin (NAB). The analysis has been performed in rats at 6 months of age. The increased urinary protein excretion of MNS, which was even higher in NB, paralleled the appearance of glomerular and interstitial alterations as described in the text. The presence of MHS α-adducin in MHS, NA, and NAB appeared to protect against proteinuria and glomerular damage. Five rats for each group were analyzed. Magnification: MHS and NAB ×400; MNS, NA, and NB ×250. Figure S4 in supplementary data shows the quantitative morphometric analysis