Table 1.

Nomenclature of GC enzymes and genes.

Mouse (Gene)	Human (Gene)	Aliases	Ligand	Tissue/cells	Comments
GC-A (Npr1)	GCA, (NPR1) NPR-A	Natriuretic Peptide Receptor A	ANP BNP	vasculature	Regulates hypertension
GC-B(Npr2)	GCB, (NPR2) (NPR-B)	Natriuretic Peptide Receptor B	CNP	Brain, bone	Null alleles associated with dwarfism
GC-C (Gucy2c)	GCC (GUCY2C)		guanylin uroguanylin enterotoxin	Intestines	Null allele insensitive to enterotoxins
GC-D (Gucy2d)	GCD (GUCY2E)	Olfactory neuroepithelia (ONE)-GC	guanylin uroguanylin	Subset of Olfactory neurons	Pseudogene in primates
GC-E (Gucy2e)	RetGC-1 (GUCY2D)	ROS-GC1, GC1	GCAPs	rods and cones, pineal	Null alleles associated with LCA-1
GC-F (Gucy2f)	RetGC-2 (GUCY2F)	ROS-GC2, GC2	GCAPs	Rods	Mutant alleles in cancer cells
GC-G (Gucy2g)	GCG (GUCY2G)		unknown	mouse testis, kidney	Pseudogene in human