Figure 5.
Alternatively spliced forms of REL in human lymphoma cell lines and in primary lymphocytes. (a) Schematic of the wild-type REL protein at the top with diagrams of the exons used to generate the three REL mRNAs found in human lymphoma cell lines. Exon architecture and amino acids encoded by each isoform are indicated (RHD, Rel homology domain; RID, REL inhibitory domain; I and II, transactivation subdomains I and II). (b) PCR amplification was performed on cDNA isolated from the indicated lymphoma cell lines and from three samples of non-neoplastic tonsil tissues. The sizes of the PCR products are indicated.