FIGURE 1.
Endogenous c-Jun determines mammary epithelial tumor cell migration velocity. A, schematic representation of experimental protocol in which MMTV-ErbB2-c-junf/f double transgenic mice tumors were analyzed. B, Western blot analysis of c-junf/f METs demonstrating reduction in c-Jun abundance upon transduction with Ad-Cre. C, mammary epithelial tumor cells from c-junf/f cells transduced with either Ad-Cre or Ad-null were assessed in a wound healing assay (B). D, video microscopy of either c-junf/f or c-jun−/− cells. E, video microscopy data were used to determine the cellular velocity of the MET cells. Error bars indicate S.E.