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ITC titrations of SIRT1 peptide substrate complexes with SRT1460. Top panels, binding isotherm for titrations of SRT1460 to the SIRT1-TAMRA Peptide 1 complex (A) and the SIRT1-Native Peptide 3 complex (B). Bottom panels, integrated fit with a one-site binding model. The amino acid sequence of the TAMRA Peptide 1 and the Native Peptide 3 are shown in supplemental Table S1.
