Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Jan 4;285(11):8395–8407. doi: 10.1074/jbc.M109.038638

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 8. — Schematic representation of GADD45β-driven C/EBPβ modulation of Col10a1 during chondrocyte terminal differentiation. GADD45β through the MTK1/MKK3/6/p38 axis may promote chondrocyte terminal differentiation via p38-dependent phosphorylation of the C/EBPβ-TAD4 to promote protein-protein interactions with CBP-p300 or TAF2B/TBP to recruit the polymerase II complex and enhance transcriptional activation of Col10a1. GADD45β-C/EBP-responsive element 1 (GCRE) is the binding site for C/EBPβ that we identified in the Col10a1 promoter (TCATGCAATA). TF, transcription factor.

HHS Vulnerability Disclosure