FIGURE 1.

Alignment of p40/ARPC1 primary sequences from S. cerevisiae (S.c.), H. sapiens (H.s.), B. taurus (B.t.), and S. pombe (S.p.). Bovine structural elements are designated above the primary sequences. The arrows represent β-sheets, and boxes represent α-helices. The seven propeller blades of p40/ARPC1 are colored-coded: green (blade 1), blue (blade 2), pink (blade 3), cyan (blade 4), orange (blade 5), lavender (blade 6), and gray (blade 7), so that numbering is consistent with Fig. 2. Residues that are identical in all four species are shaded in dark gray; similar residues are shaded in light gray. Allele numbers and mutations are shown above the S. cerevisiae sequence. Sequences internally deleted in arc40Δ311–340 are marked by a red line. Residues included in the arm domain peptide (residues 306–355) are underlined in green.