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. Author manuscript; available in PMC: 2010 Mar 5.
Published in final edited form as: Neuropathol Appl Neurobiol. 2007 Oct 26;34(3):272–283. doi: 10.1111/j.1365-2990.2007.00888.x

Fig. 2. LRRK2 is extensively expressed in the cytoplasm of neurons of the normal CNS. LRRK2 localises to the nuclear envelope.

Fig. 2

All images from adult control tissue unless stated otherwise. (A) Substantia nigra. (B) Hippocampus. (C) Substantia nigra (infant control). (D) Dentate granule cells. (E) Striatum, showing large (arrow) and medium neurons (arrowhead). (F) Anterior horn of the spinal cord (infant control). (G) CA2 sector of the hippocampus. (H) CA4 sector of the hippocampus. (I) III nerve nucleus. (J) Red nucleus (PD case). (K) CA4 sector of the hippocampus. (L) CA4 sector of the hippocampus. Single slide from a z-stack three dimensional reconstruction. LRRK2 (red colour) in an apparent intranuclear rod is actually at the nuclear membrane. In G-L, arrows point at the nuclear membrane enhancement of staining. Arrowheads point at nuclear indentations and rods. The antibody used is shown in each image. Slides were counterstained with haematoxylin/DAPI (L). Scale bars: 100 μm in A and B, rest, 10 μm.