Table 2. Expression of LRRK2 in normal human adult brain.
Semiquantitative analysis of neuronal LRRK2 expression using the C-terminal antibody. Very similar results were observed for the N-terminal and Ev antibodies.
| Brain area | LRRK2 |
|---|---|
| Isocortex | + |
| Hippocampal area | |
| Fascia dentata | ++ |
| CA4-CA3 | ++ |
| CA2-CA1 | + |
| Subiculum | ++ |
| Entorhinal cortex | + |
| Transentorhinal | + |
| Cerebral grey nuclei | |
| Striatum (large neurons) | ++ |
| (medium) | + |
| Globus pallidus | ++ |
| Claustrum | + |
| Basal nucleus | ++ |
| Thalamus | ++ |
| Amygdala | ++ |
| Lateral geniculate nucleus | ++ |
| Subthalamus | + |
| Cerebellum | |
| Dentate nucleus | ++ |
| Purkinje cells | + |
| Molecular layer | + |
| Granular layer (Golgi cells) | ++ |
| Midbrain | |
| SN | ++ |
| Red nucleus | ++ |
| Superior colliculus | + |
| Periaqueductal grey | + |
| III nerve nucleus | +++ |
| Pons | |
| Locus caeruleus | ++ |
| Pontine nuclei | ++ |
| Raphe | ++ |
| Medulla | |
| XII nerve nucleus | +++ |
| IX/X dorsal motor nucleus | ++ |
| Nucleus solitarius | + |
| Nucleus cuneatus | +++ |
| Nucleus oblongatae | + |
| Nucleus ambiguus | + |
| Inferior olive | +++ |
| Cord | |
| Motoneurons | +++ |
Scale: + = weak, ++ = moderate, +++ = strong