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Generation of enucleated RBC from one CD34+ cell in a LDA. Wells were analyzed for the percentage of enucleated RBC on day 18 (each dot is the result for one well). Data are from three control subjects and three patients. 5q(del) clones were able to generate enucleated RBC to a similar extent as controls: median level of enucleation: 62% (range, 3–90) vs. 52% (range, 1–75) respectively (P=0.7).
