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Successful transduction of CLL cells with lentivirus. (A) Treatment of CLL cells with lentivirus containing the genetic codes for CD38 (i), GFP (ii), and a truncated rat CD2 (iii) resulted in high levels of transduction (87%, 70% and 43%, respectively). (B) CLL cells from a CD38 negative patient (i) were infected with a CD38 lentivirus and 94% transduction was achieved (ii). Infection with a GFP control lentivirus saw a 9.7% increase in CD38 expression (iii).
