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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Nov 14;20(1):83–86. doi: 10.1016/j.bmcl.2009.11.036

Scheme 3.

Scheme 3

Reagents and conditions: (i) Br2 (2 equiv), MeSO3H, 110°C, 16 h: products 8e (25%) and 2e (11%), 8f (30%) and 2f (8%), 8g (33%) and 2g (6%), 8h (41%) and 2h (5%); (ii) t-BuOK (1 equiv), THF, 16 h: products 2e (26%), 2f (47%), 2g (37%), and 2h (25%).