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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Nitric Oxide. 2010 Jan 25;22(3):242–257. doi: 10.1016/j.niox.2010.01.005

Figure 7.

Figure 7

TNFSFR and NF-κB signaling activation during macrophage activation: CpG late responses. Downstream effector molecules for these up regulated receptors were up regulated (TRAF3, SAPK2, TRAF1, FLIP, JUN) and the alternate pathway leading to apoptosis was down regulated (Casp8, APAF-1, BAG-1, PCD1, CAD), lending support to the conclusion that the entire pathway was activated and steered away from the apoptotic outcome. AP-1 components were up regulated, IκB was down regulated, and transcripts associated with transcription factor binding to DNA and protein products (TNF, COX2, iNOS) were increased (IL-1, A20) at late time points after treatment with CpG. Green = down regulated, red = up regulated, * = activation, P = phosphorylation, → = binds/interacts with, —| = blocks binding/interaction of.