Table 3.
Structural and Morphological Abnormalities in Genetic Schizophrenia Models
| Neuropathohistology |
||||||
| Model | Imaging | Gross Anatomy | Cytoarchitecture | Pyramidal Neurons | Interneurons | Glia |
| Dysbindin | Morphological changes in asymmetrical synapses in CA1 (Chen et al71) | |||||
| NRG1 | Increased lateral ventricles (Chen et al71), Normal myelin (Brinkmann et al74) | Reduced spine density in Hc (Chen et al71, Barros et al75) | ||||
| ErbB4 | Normal myelin (Brinkmann et al74) | Reduced spine density in cortex, Hc (Barros et al75) | Reduced parvalbumin IR (Fisahn et al76) Reduced calbindin IR (Flames et al77) | Increased oligodendrocyte number, thinner myelin (Roy et al78) | ||
| Disc1 | Smaller brain volume, Enlarged lateral ventricles (Hikida et al81, Pletnikov et al) | Enlarged lateral ventricles partial agenesis of corpus callosum, thinner cortex (Shen et al83) | Altered organization of dentate granule cells (Kvajo et al86) | Shorter dendrites (Pletnikov et al, Li et al85, Shen et al83) | Reduced parvalbumin IR at mPFC, Hc (Hikida et al81, Shen et al83) | |
| Akt-1 | Altered pyramidal cell morphology at PFC (Lai et al87) | No change in parvalbumin and calbindin density in the PFC (Lai et al87) | ||||
| Δ22q11 (COMT, GNB1L, PRODH, ZDHHC8) | Decreased spine density and dendritic complexity (Mukai et al89) | |||||
Note: CA1, cornus ammonis 1; DISC1, disrupted in schizophrenia-1; Hc, hippocampus; IR, immunoreactivitiy; mPFC, medial prefontal cortex.