Table 3.
List of 13 masses detected among the top 50 masses inclusive to all three discovery projects
| GCI | ||||||
|---|---|---|---|---|---|---|
| Rank order | Detected mass | Molecular formula | Part per million | Analysis mode | P value | Ratio (CRC/normal) |
| 6 | 446.3406 | C28H46O4 | 2.22 | NAPCI | 6.4E-13 | 0.31 |
| 13 | 448.3563 | C28H48O4 | 2.32 | NAPCI | 2.5E-12 | 0.41 |
| 8 | 466.3661 | C28H50O5 | 0.59 | NAPCI | 9.4E-13 | 0.25 |
| 7 | 468.3840 | C28H52O5 | 5.39 | NAPCI | 9.0E-13 | 0.27 |
| 21 | 492.3829 | C30H52O5 | 2.89 | NAPCI | 8.5E-11 | 0.33 |
| 24 | 494.3977 | C30H54O5 | 1.16 | NAPCI | 1.9E-10 | 0.35 |
| 29 | 518.3976 | C32H54O5 | 0.92 | NAPCI | 1.6E-09 | 0.37 |
| 12 | 538.4259 | C32H58O6 | 4.76 | NAPCI | 2.5E-12 | 0.30 |
| 44 | 574.4607 | C36H62O5 | 1.7 | NAPCI | 1.6E-08 | 0.40 |
| 26 | 576.4771 | C36H64O5 | 2.99 | NAPCI | 3.0E-10 | 0.37 |
| 32 | 578.4931 | C36H66O5 | 3.59 | NAPCI | 3.2E-09 | 0.34 |
| 11 | 592.4711 | C36H64O6 | 1.37 | NAPCI | 2.2E-12 | 0.27 |
| 15 | 594.4851 | C36H66O6 | 1.41 | NAPCI | 6.3E-12 | 0.26 |
| Seracare | ||||||
| 45 | 446.3413 | C28H46O4 | 3.79 | NAPCI | 1.8E-06 | 0.36 |
| 9 | 448.3570 | C28H48O4 | 3.88 | NAPCI | 1.6E-08 | 0.36 |
| 3 | 466.3664 | C28H50O5 | 1.23 | NAPCI | 8.5E-10 | 0.34 |
| 6 | 468.3847 | C28H52O5 | 6.89 | NAPCI | 4.9E-09 | 0.36 |
| 17 | 492.3835 | C30H52O5 | 4.11 | NAPCI | 4.6E-08 | 0.42 |
| 34 | 494.3971 | C30H54O5 | 0.05 | NAPCI | 6.6E-07 | 0.41 |
| 11 | 518.3968 | C32H54O5 | 0.63 | NAPCI | 2.2E-08 | 0.33 |
| 18 | 538.4263 | C32H58O6 | 5.5 | NAPCI | 7.8E-08 | 0.38 |
| 32 | 574.4595 | C36H62O5 | 0.39 | NAPCI | 6.1E-07 | 0.32 |
| 42 | 576.4768 | C36H64O5 | 2.47 | NAPCI | 1.0E-06 | 0.37 |
| 49 | 578.4933 | C36H66O5 | 3.93 | NAPCI | 3.2E-06 | 0.42 |
| 30 | 592.4721 | C36H64O6 | 3.06 | NAPCI | 5.6E-07 | 0.27 |
| 50 | 594.4851 | C36H66O6 | 1.41 | NAPCI | 3.7E-06 | 0.32 |
| Osaka | ||||||
| 6 | 446.3400 | C28H46O4 | 0.87 | NESI | 1.8E-10 | 0.44 |
| 13 | 448.3556 | C28H48O4 | 0.76 | NESI | 2.2E-09 | 0.54 |
| 1 | 466.3663 | C28H50O5 | 1.02 | NESI | 2.9E-12 | 0.50 |
| 5 | 468.3815 | C28H52O5 | 0.05 | NESI | 1.8E-10 | 0.49 |
| 4 | 492.3814 | C30H52O5 | 0.15 | NESI | 7.1E-11 | 0.57 |
| 23 | 494.3969 | C30H54O5 | 0.45 | NESI | 2.0E-07 | 0.62 |
| 39 | 518.3975 | C32H54O5 | 0.72 | NAPCI | 5.8E-06 | 0.52 |
| 19 | 538.4237 | C32H58O6 | 0.67 | NESI | 4.7E-08 | 0.58 |
| 16 | 574.4600 | C36H62O5 | 0.48 | NESI | 3.8E-09 | 0.42 |
| 7 | 576.4756 | C36H64O5 | 0.39 | NESI | 3.0E-10 | 0.42 |
| 14 | 578.4910 | C36H66O5 | 0.04 | NESI | 2.6E-09 | 0.50 |
| 15 | 592.4703 | C36H64O6 | 0.02 | NESI | 3.3E-09 | 0.41 |
| 3 | 594.4859 | C36H66O6 | 0.07 | NESI | 6.8E-11 | 0.40 |
Indicated are the rank order based on P-value, detected accurate mass, the computationally predicted molecular formula, the mass difference between the detected mass and mass of the predicted molecular formula in part per million, the mode of analysis (electrospray ionization, ESI; atmospheric pressure chemical ionization, APCI), the P-value (based on an unpaired student's t-test) between the average peak intensity of control subjects versus colorectal cancer (CRC) patients, and the average peak intensity ratio between CRC patients and controls.