Figure 6.

Clust8-Sub25 - Novel microenvironment motif with a potential structural role. Five representative microenvironments from a total of 11 are shown. This set of microenvironments is characterized by the central CYS based in a helix with the sidechain surrounded by an abundance of aliphatic, hydrophobic sidechains (ILE, LEU, VAL). Cysteines are often important for stabilizing protein structures, and the absence of reactive sidechains combined with the striking similarity between members of this cluster suggest a potential structural role for this microenvironment.