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. Author manuscript; available in PMC: 2010 Mar 5.
Published in final edited form as: Cancer Res. 2007 Jan 1;67(1):318–325. doi: 10.1158/0008-5472.CAN-06-2164

Figure 3.

Figure 3

[5,5′-3H2]AHPN binding to Sin3A- and 3-Cl-AHPC–mediated apoptosis is dependent on HSP90 ATPase activity and Sin3A expression. MDA-MB-468 cells were incubated with either vehicle or 1 μg/mL geldanamycin (Geld) for 2 h and then exposed to AHPN and 3-Cl-AHPC or vehicle for 24 h. 3-Cl-AHPC induction of Sin3A-associated HDAC activity (A), [5,5′-3H2]AHPN Sin3A binding (B), and 3-Cl-AHPC–mediated apoptosis (C) in cells treated with and without geldanamycin. D, effect of Sin3A loss of expression in MDA-MB-468 cells on 3-Cl-AHPC–mediated apoptosis. Cells were exposed to vehicle or 1 μmol/L 3-Cl-AHPC for varying times.