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. 2010 Mar 8;5(3):e9582. doi: 10.1371/journal.pone.0009582

Figure 7. Interference of the electron transport chain affects the artemisinin's action.

Figure 7

(A) An isobologram for DPI and artemisinin. Data points above the line indicate antagonism between DPI and artemisinin. FIC: fractional inhibitory concentration. DPI: diphenylene iodonium chloride. (B) An isobologram for DPI and chloroquine (CQ). (C) Effect of DPI on the ROS promoting ability of artemisinin. ROS was monitored using the DCFH-DA assay. (D) Effect of DPI on the depolarizing ability of artemisinin. Δψ of isolated P. berghei mitochondria was assessed by measuring the Δψ-dependent uptake of Rh123. (E) Iron chelator DFO inhibits ETC activity. (F) Iron chelator DFO reduces artemisinin-induced ROS production in isolated malarial mitochondria. n = 3. Data were shown as mean ± SEM. ** p<0.01 versus conrol; *** p<0.001 versus control; ## p<0.01 versus Art.