Table 1.
Differentially expressed genes in the oral mucosa of smokers vs. never smokers with corresponding fold-changes and P values. Detailed annotations are provided at http://physiology.med.cornell.edu/go/smoke.
| Gene Name | Affymetrix ID | Fold | P value | Gene Title |
|---|---|---|---|---|
| S100A7 | 205916_at | 4.4 | 3.1E-02 | S100 calcium binding protein A7 |
| RPTN | 1553454_at | 4.3 | 1.7E-02 | repetin |
| CYP1B1 | 202437_s_at | 4.2 | 1.4E-11 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| CYP1B1 | 202436_s_at | 3.2 | 6.9E-10 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| LOR | 207720_at | 3.2 | 9.4E-03 | loricrin |
| CEACAM7 | 206198_s_at | 3.0 | 3.1E-02 | carcinoembryonic antigen-related cell adhesion molecule 7 |
| CYP1A1 | 205749_at | 2.5 | 1.1E-07 | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| CYP1B1 | 202435_s_at | 2.5 | 2.7E-08 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| HTR3A | 216615_s_at | 2.2 | 7.7E-03 | 5-hydroxytryptamine (serotonin) receptor 3A |
| GPX2 | 202831_at | 2.1 | 3.1E-04 | glutathione peroxidase 2 (gastrointestinal) |
| FCGBP | 203240_at | 2.0 | 2.9E-05 | Fc fragment of IgG binding protein |
| --- | 227452_at | 2.0 | 7.8E-10 | Full-length cDNA clone CS0DD005YM12 of Neuroblastoma Cot 50-normalized of Homo sapiens (human) |
| CCL26 | 223710_at | 1.9 | 2.8E-02 | chemokine (C-C motif) ligand 26 |
| PNLIPRP3 | 1558846_at | 1.9 | 6.2E-03 | pancreatic lipase-related protein 3 |
| ALOX12B | 207381_at | 1.9 | 1.2E-02 | arachidonate 12-lipoxygenase, 12R type |
| LOC388610 | 227862_at | 1.9 | 2.9E-02 | hypothetical LOC388610 |
| CD207 | 220428_at | 1.8 | 1.3E-05 | CD207 molecule, langerin |
| CHRNA3 | 210221_at | 1.7 | 2.0E-04 | cholinergic receptor, nicotinic, alpha 3 |
| CYTL1 | 219837_s_at | 1.7 | 1.6E-07 | cytokine-like 1 |
| NQO1 | 201468_s_at | 1.7 | 6.7E-04 | NAD(P)H dehydrogenase, quinone 1 |
| NQO1 | 210519_s_at | 1.6 | 2.1E-03 | NAD(P)H dehydrogenase, quinone 1 |
| NQO1 | 201467_s_at | 1.5 | 4.9E-03 | NAD(P)H dehydrogenase, quinone 1 |
| CLEC7A | 1555756_a_at | 1.6 | 1.6E-02 | C-type lectin domain family 7, member A |
| CLEC7A | 221698_s_at | 1.6 | 9.4E-04 | C-type lectin domain family 7, member A |
| LOC344887 | 241418_at | 1.6 | 6.2E-03 | similar to hCG2041270 |
| PTGES | 210367_s_at | 1.6 | 4.9E-02 | prostaglandin E synthase |
| KRT10 | 207023_x_at | 1.6 | 3.5E-02 | keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris) |
| C10orf99 | 227736_at | 1.6 | 9.4E-03 | chromosome 10 open reading frame 99 |
| C10orf99 | 227735_s_at | 1.6 | 1.2E-02 | chromosome 10 open reading frame 99 |
| ALDH3A1 | 205623_at | 1.6 | 2.9E-05 | aldehyde dehydrogenase 3 family, memberA1 |
| ALOX15B | 206714_at | 1.6 | 3.5E-02 | arachidonate 15-lipoxygenase, type B |
| UGT1A6 /// | 221305_s_at | 1.5 | 1.1E-02 | UDP glucuronosyltransferase 1 family, polypeptide A6 /// UDP |
| UGT1A8 /// | glucuronosyltransferase 1 family, polypeptide A8 /// | |||
| UGT1A9 | UDP glucuronosyltransferase 1 family, polypeptide A9 | |||
| MUC1 | 213693_s_at | 1.5 | 4.7E-02 | mucin 1, cell surface associated |
| AKR1C1 /// | 1555854_at | 1.5 | 1.9E-02 | aldo-keto reductase family 1, member C1 /// |
| AKR1C2 | aldo-keto reductase family 1, member C2 | |||
| AHRR/// | 229354_at | 1.5 | 3.8E-08 | aryl-hydrocarbon receptor repressor /// |
| PDCD6 | programmed cell death 6 | |||
| LYPD5 | 236039_at | 1.5 | 4.7E-02 | LY6/PLAUR domain containing 5 |
| UGT1A1 /// | 215125_s_at | 1.5 | 2.3E-03 | UDP glucuronosyltransferase 1 family, polypeptide UDP |
| UGT1A3 to | glucuronosyltransferase 1 family, polypeptide A3 to A10 | |||
| UGT1A10 | ||||
| CCL5 | 1405_i_at | 1.5 | 1.7E-02 | chemokine (C-C motif) ligand 5 |
| UGT1A1 /// | 207126_x_at | 1.5 | 3.1E-04 | UDP glucuronosyltransferase 1 family, polypeptide A1/// |
| UGT1A4 /// | UDP glucuronosyltransferase 1 family, polypeptide A4/// | |||
| UGT1A6 /// | UDP glucuronosyltransferase 1 family, polypeptide A6/// | |||
| UGT1A8 to | UDP glucuronosyltransferase 1 family, polypeptide A8 to A10 | |||
| UGT1A10 | ||||
| CD1a | 210325_at | 1.5 | 9.6E-03 | CD1a molecule |
| LYVE1 | 220037_s_at | −1.5 | 1.0E-02 | lymphatic vessel endothelial hyaluronan receptor 1 |
| YOD1 | 215150_at | −1.5 | 3.0E-02 | YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) |
| CCL18 | 209924_at | −1.5 | 3.2E-02 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
| ANKRD37 | 227337_at | −1.5 | 3.7E-02 | ankyrin repeat domain 37 |
| SOX9 | 202936_s_at | −1.5 | 2.4E-03 | SRY (sex determining region Y)-box 9 |
| SOX9 | 202935_s_at | −1.5 | 1.1E-02 | SRY (sex determining region Y)-box 9 |
| LEPR | 211355_x_at | −1.5 | 4.4E-03 | leptin receptor |
| LEPR | 211354_s_at | −1.6 | 4.3E-03 | leptin receptor |
| LEPR | 211356_x_at | −1.6 | 2.4E-03 | leptin receptor |
| IGF2BP3 | 203819_s_at | −1.7 | 5.4E-04 | insulin-like growth factor 2 mRNA binding protein 3 |
| IGF2BP3 | 203820_s_at | −1.6 | 1.4E-02 | insulin-like growth factor 2 mRNA binding protein 3 |
| CCL18 | 32128_at | −1.6 | 3.4E-02 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
| HIG2 | 1554452_a_at | −1.9 | 3.8E-02 | hypoxia-inducible protein 2 |
| PEG3 | 209242_at | −2.1 | 1.1E-02 | paternally expressed 3 |