Table 4.
Genes that are overexpressed in the oral mucosa of smokers are also commonly overexpressed in the airways of smokers. Differentially expressed genes (fold-changes) in the oral and airway mucosa of smokers vs. never smokers with associated P values (Anova). The CEACAM family genes CEACAM5 and CEACAM6 are induced in the airways of smokers whereas CEACAM7 is induced in the oral mucosa of smokers. FCGBP is induced in the oral mucosa while repressed in the airway of smokers.
| Oral vs. Airway | ||||
|---|---|---|---|---|
| Gene Name | Affymetrix ID | Oral Mucosa Fold (P) | Airway Fold (P) | Gene Title |
| CYP1B1 | 202437_s_at | 4.2 (1.1e-11) | 8.1 (1.2e-07) | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| CYP1B1 | 202436_s_at | 3.2 (5.5e-10) | 7.1 (2.4e-07) | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| CYP1A1 | 205749_at | 2.5 (3.1e-05) | 2.8 (5.6e-04) | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| GPX2 | 202831_at | 2.1 (3.1e-04) | 3.3 (5.8e-14) | glutathione peroxidase 2 (gastrointestinal) |
| NQO1 | 201468_s_at | 1.7 (6.9e-04) | 3.7 (4.1e-13) | NAD(P)H dehydrogenase, quinone 1 |
| NQO1 | 210519_s_at | 1.6 (1.9e-03) | 3.6 (4.5e-14) | NAD(P)H dehydrogenase, quinone 1 |
| NQO1 | 201467_s_at | 1.5 (4.4e-03) | 3.2 (6.7e-12) | NAD(P)H dehydrogenase, quinone 1 |
| ALDH3A1 | 205623_at | 1.6 (7.5e-04) | 6.5 (3.4e-12) | aldehyde dehydrogenase 3 family, memberA1 |
| UGT1A1 /// | 215125_s_at | 1.5 (2.1e-03) | 2.2 (1.4e-08) | |
| UGT1A3 to | UDP glucuronosyltransferase 1 family, | |||
| UGT1A10 | polypeptide A1 /// A3 to A10 | |||
| UGT1A1 /// | 207126_x_at | 1.5 (3.1e-04) | 1.8 (2.0e-08) | |
| UGT1A4 /// | ||||
| UGT1A6 /// | ||||
| UGT1A8 to | UDP glucuronosyltransferase 1 family, | |||
| UGT1A10 | polypeptide A1 /// A4 /// A6 /// A8 to A10 | |||
| MUC1 | 207847_s_at | (>0.05) | 1.6 (0.021) | mucin 1, cell surface associated |
| MUC1 | 213693_s_at | 1.5 (0.043) | 1.4 (0.015) | mucin 1, cell surface associated |
| CEACAM5 | 201884_at | 1.3 (0.011) | 5.4 (3.8e-11) | Carcinoembryonic antigen-related cell adhesion molecule 5 |
| CEACAM6 | 203757_s_at | (>0.05) | 2.4 (1.3e-4) | Carcinoembryonic antigen-related cell adhesion molecule 6 |
| CEACAM6 | 211657_at | (>0.05) | 2.3 (2.1e-4) | Carcinoembryonic antigen-related cell adhesion molecule 6 |
| CEACAM7 | 206198_s_at | 3.0 (0.031) | (>0.05) | Carcinoembryonic antigen-related cell adhesion molecule 7 |
| FCGBP | 203240_at | 2.0 (3.1e-05) | −2.3 (0.01) | Fc fragment of IgG binding protein |