Table 2.
Association of serum adiponectin isoforms levels and insulin resistance-related traits in 640 non-diabetic individuals from 235 nuclear families
HMW Adiponectin (µg/ml) | MMW Adiponectin (µg/ml) | LMW Adiponectin (µg/ml) | ||||
---|---|---|---|---|---|---|
β±SE | P value | β±SE | P value | β±SE | P value | |
BMI (Kg/m2) | −0.12±0.02 | 3.3×10−7 | −0.0043±0.013 | 0.75 | −0.012±0.017 | 0.48 |
Waist circumference (cm) | −0.05±0.0099 | 6.5×10−8 | −0.0069±0.0055 | 0.21 | −0.012±0.007 | 0.08 |
SBP (mmHg) | −0.0076±0.0083 | 0.36 | −0.0028±0.0044 | 0.53 | −0.00042±0.0055 | 0.94 |
DBP (mmHg) | −0.014±0.013 | 0.27 | −0.0011±0.0068 | 0.87 | −0.0067±0.0083 | 0.42 |
FBG (mg/dl) | −0.04±0.01 | 8.7×10−5 | −0.0076±0.0059 | 0.20 | −0.015±0.0073 | 0.05 |
Insulin (µU/ml) | −2.8±0.49 | 2.9×10−9 | −0.23±0.25 | 0.35 | −0.19±0.31 | 0.54 |
HOMAIR | −2.7±0.43 | 5.4×10−10 | −0.26±0.24 | 0.27 | −0.27±0.29 | 0.35 |
Triglycerides (mg/dl) | −2.2±0.47 | 3.2×10−6 | −0.40±0.26 | 0.13 | −0.0044±0.032 | 0.99 |
HDL cholesterol (mg/dl) | 0.068±0.0079 | 6.3×10−17 | 0.015±0.004 | 1.1×10−3 | 0.012±0.005 | 2.9×10−2 |
MS score | −0.56±0.11 | 1.2×10−7 | −0.13±0.056 | 1.7×10−2 | −0.06±0.07 | 0.36 |
CRP (mg/L) | −1.5±1.4 | 0.29 | 0.25±0.85 | 0.77 | 0.49±1.06 | 0.64 |
Smoking habit | −0.13±0.2 | 0.59 | −0.04±0.1 | 0.69 | −0.02±0.16 | 0.90 |
Physical exercise | 0.25±0.25 | 0.32 | 0.2±0.13 | 0.12 | 0.03±0.16 | 0.19 |
The β coefficients represent the change in adiponectin levels for 1 unit increase in the predictor. HMW: High Molecular Weight; MMW: Medium Molecular Weight; LMW: Low Molecular Weight; BMI: Body Mass Index; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; FBG: Fasting Blood Glucose; HOMAIR homeostasis model assessment of insulin-resistance; HDL-Cholesterol: high-density lipoprotein cholesterol; MS score: Metabolic Syndrome score; CRP: C-reactive protein. Analyses are adjusted for age, age2, gender, smoking habit and physical exercise.