Table 4.
Genetic (ρg) correlations between adiponectin isoforms levels and insulin resistance-related traits in 640 non-diabetic individuals from 235 nuclear families
HMW Adiponectin | MMW Adiponectin | LMW Adiponectin | ||||
---|---|---|---|---|---|---|
ρg±SE | P value | ρg±SE | P value | ρg±SE | P value | |
BMI | −0.21±0.11 | 0.08 | −0.03±0.11 | 0.78 | −0.03±0.11 | 0.78 |
Waist circumference | −0.23±0.12 | 0.08 | −0.05±0.12 | 0.70 | −0.05±0.12 | 0.70 |
SBP | −0.006±0.14 | 0.97 | −0.21±0.13 | 0.11 | −0.21±0.13 | 0.11 |
DBP | −0.24±0.14 | 0.09 | −0.02±0.13 | 0.85 | −0.02±0.13 | 0.85 |
FBG | −0.15±0.14 | 0.28 | −0.10±0.14 | 0.45 | −0.10±0.14 | 0.45 |
Insulin | −0.37±0.14 | 1.1×10−5 | −0.07±0.14 | 0.66 | −0.07±0.14 | 0.66 |
HOMAIR | −0.32±0.14 | 4.9×10−3 | −0.08±0.14 | 0.62 | −0.08±0.14 | 0.62 |
Triglycerides | −0.17±0.12 | 0.14 | −0.02±0.12 | 0.88 | −0.02±0.12 | 0.88 |
HDL cholesterol | 0.22±0.11 | 1.6×10−2 | 0.14±0.11 | 0.21 | 0.14±0.11 | 0.21 |
MS score | −0.32±0.14 | 4.2×10−2 | −0.13±0.14 | 0.39 | −0.13±0.14 | 0.39 |
CRP | −0.24±0.55 | 0.65 | −0.17±0.51 | 0.72 | −0.69±0.57 | 0.19 |
HMW: High Molecular Weight; MMW: Medium Molecular Weight; LMW: Low Molecular Weight; BMI: Body Mass Index; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; FBG: Fasting Blood Glucose; HOMAIR homeostasis model assessment of insulin-resistance; HDL-Cholesterol: high-density lipoprotein cholesterol; MS score: Metabolic Syndrome score; CRP: C-reactive protein.
Analyses are adjusted for age, age2, gender, smoking habit and physical exercise.