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. 2010 Feb 9;102(5):898–907. doi: 10.1038/sj.bjc.6605543

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Copyright © 2010 Cancer Research UK

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Upper gastrointestinal series (A) and gastro-fibrscopy (B) showed diffusely infiltrating carcinomas in which ulceration is usually not a marked feature (arrows). Histology of the primary tumour and the peritoneal metastatic tumour showed poorly differentiated adenocarcinoma (C). Primary gastric tumour accompanied by fibrosis. Immunostaining of hypoxia-inducible factor-1α (HIF-1α) and carbonic anhydrase 9 (CA9) showed that hypoxic lesions were present in both the primary tumour and the peritoneal metastatic tumour (C).