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. 2010 Feb 16;102(5):827–832. doi: 10.1038/sj.bjc.6605560

Table 1. Sampling schedule of HuHMFG1.

  First administration (h)
Posology (mg kg−1) Pre-dose EOI a 1.5 4 6 12 24 48 72 144 168 216 240 312 336 648 672 840
 1 ✓   ✓   ✓ ✓ ✓ ✓   ✓   ✓   ✓     ✓ ✓
 3a     ✓   ✓ ✓ ✓ ✓   ✓   ✓   ✓   ✓    
 3b ✓ ✓   ✓ ✓ ✓ ✓   ✓   ✓   ✓ ✓ ✓ ✓    
 9 ✓ ✓   ✓ ✓ ✓ ✓   ✓ ✓                
 16 ✓ ✓   ✓ ✓ ✓ ✓   ✓ ✓                
  Following administrations
Posology (mg kg−1) Pre-dose       EOI       Day 3       Day 5     Day 8    
 1 ✓       ✓                          
 3 ✓       ✓       ✓       ✓     ✓    
 9 ✓       ✓       ✓       ✓          
 16 ✓       ✓       ✓       ✓          
  After the last administration
Posology (mg kg−1) Day 3   Day 5   Day 7   Day 10   Day 20   Day 28   Week 10   Week 16   Week 22  
 1         ✓   ✓   ✓                  
 3 ✓   ✓       ✓   ✓   ✓   ✓   ✓   ✓  
 9 ✓   ✓               ✓   ✓       ✓  
 16 ✓   ✓               ✓   ✓   ✓   ✓  

Abbreviation: EOI=end of infusion.

The last administration was undertaken if no toxicity was observed.

a

Performed with three patients.

b

Performed with six patients.