Table 3. Population pharmacokinetic parameters of HuHMFG1 and bootstrap evaluation.
|
Final model original data
|
Bootstrap evaluation
|
|||
|---|---|---|---|---|
| Parameter | Mean | s.d. | Mean | s.d. |
| V1 (l) | ||||
| θ | 3.31 | 0.14 | 3.29 | 0.13 |
| ω2 | 0.042 | 0.010 | 0.040 | 0.010 |
| CL (l h −1 ) | ||||
| θ | 0.016 | 0.002 | 0.016 | 0.002 |
| ω2 | 0.062 | 0.018 | 0.059 | 0.020 |
| Q (l h −1 ) | ||||
| θ | 0.017 | 0.004 | 0.018 | 0.004 |
| ω2 | NA | NA | NA | NA |
| V2 (l) | ||||
| θ | 2.33 | 0.42 | 2.32 | 0.37 |
| ω2 | NA | NA | NA | NA |
| COV CL | ||||
| θ | 0.0036 | 0.0012 | 0.0035 | 0.0012 |
| σ12 (proportional) | ||||
| θ | 0.034 | 0.004 | 0.033 | 0.004 |
| σ22 (additive) (mg l−1) | ||||
| θ | 2.26 (fixed) | NA | 2.26 (fixed) | NA |
Abbreviations: V1=volume of the central compartment; V2=peripheral volume; Q=inter-compartmental clearance; θ=value of the corresponding parameter; ω2=value of the inter-subject variability associated with the corresponding parameter; COVCL=value of the parameter associated with the equation of the covariate; σ12: proportional part of the residual error; σ22=additive part of the residual error; NA=not assessable.