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. 2010 Feb 9;102(5):844–851. doi: 10.1038/sj.bjc.6605561

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Copyright © 2010 Cancer Research UK

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Effects of TGF-β1 and Ki26894 on morphological characteristics of gastric cancer cells. Epithelial-to-mesenchymal transition (arrow heads) by TGF-β1 (10 ng ml⁻¹) was shown in scirrhous gastric cancer cell lines, OCUM-2MLN and OCUM-12, but not in non-scirrhous gastric cancer cell lines, MKN-45 and MKN-74. Pseudopod formation was remarkable in OCUM-12 cells in the presence of TGF-β1. Epithelial-to-mesenchymal transition by TGF-β1 in scirrhous gastric cancer cells was inhibited by Ki26894 (10 μM).