Table 2.
Volume and Surface Area Dimensions of the Transverse-Axial Tubule System. Fractions were calculated individually for all cells before averaging. Regions containing the cell's nucleus or autofluorescent beads within the images were excluded before quantitative analysis.
| Unit | Non-failing | Failing | P | |
|---|---|---|---|---|
| VTATS/VCell* | [%] | 8.67 ± 0.62 | 7.93 ± 0.64 | P = .417 |
| ATATS/VCell | [μm²/μm3] | 0.403 ± 0.026 | 0.343 ± 0.020 | P = .081 |
| ACell/ACell | [μm²/μm3] | 0.327 ± 0.033 | 0.290 ± 0.028 | P = .404 |
| AMemb/VCell | [μm²/μm3] | 0.729 ± 0.042 | 0.632 ± 0.041 | P = .111 |
| ATATS/VTATS | [μm²/μm3] | 4.682 ± 0.123 | 4.476 ± 0.197 | P = .386 |
| ATATS/AMemb | [%] | 55.68 ± 2.63 | 54.89 ± 2.12 | P = .817 |
|
| ||||
| VCell | Apparent cellular volume, that is, volume surrounded by the exterior cellular membrane |
|||
| VTATS | Intracellular volume occupied by the TATS | |||
| ATATS | Surface area of the TATS | |||
| ACell | Surface of the exterior cellular membrane | |||
| AMemb | Total membrane surface area, that is, ACell + ATATS | |||
*in previous studies V TATS/V Cell ratio is referred to as fractional volume, TATS volume fraction, or t index.