Table 6.
Cytokine levels by clinical outcome.
| Cytokine | NUD (n = 28) | GUs (n = 26) | DUs (n = 26) | GC (n = 16) |
|---|---|---|---|---|
| Protein levels, pg/mg of biopsy protein | ||||
| IL-18 | ||||
| Antrum | 223 (62–282) | 203 (31–312) | 213 (35–288) | 94 (38–276) |
| Corpus | 111 (45–251) | 100 (26–235) | 83 (37–333) | 77 (28–213) |
| IL-12p70 | ||||
| Antrum | 14 (6.7–27.1) | 12 (8.4–26) | 18 (14–52)a | 15 (10–32) |
| Corpus | 12 (6.1–20.0) | 14 (11–19) | 19 (11–38)b | 14 (12–20) |
| IFN-γ | ||||
| Antrum | 25 (13–39) | 24 (12–34) | 32 (16–62) | 30 (17–44) |
| Corpus | 16 (12–39) | 14 (13–24) | 27 (12–55) | 22 (18–27) |
| mRNA levels, 0–3 | ||||
| IL-18 | ||||
| Antrum | 2 (1–2.5) | 2.5 (0–3) | 1.5 (0–3) | 1.5 (0.5–2.5) |
| Corpus | 2 (1–3) | 2 (0–3) | 2 (1–3) | 1 (1–2.5) |
| IL-12p40 | ||||
| Antrum | 1 (0–2) | 1 (0–2) | 1 (0–3) | 1 (0.5–2) |
| Corpus | 1 (1–2) | 1 (1–2) | 2 (1–3)c | 1.5 (0.5–2.5) |
| IFN-γ | ||||
| Antrum | 2 (0–2.5) | 1 (0–2) | 2 (1–3) | 1.5 (0–2.5) |
| Corpus | 1 (0.5–2) | 1 (0–2) | 1 (0–3) | 1 (0.5–2) |
NOTE. P values for correlation between cytokine levels were calculated by Spearman’s rank test. P values are presented only if they indicate statistical significance. DUs, duodenal ulcers; GC, gastric cancer; GUs, gastric ulcers; IFN, interferon; IL, interleukin; NUD, nonulcer dyspepsia.
a
P = .027, compared with GUs; P = .058, compared with NUD.
b
P = .036, compared with NUD; P = .098, compared with GUs.
c
P = .044, compared with NUD; P = .033, compared with GUs.