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. Author manuscript; available in PMC: 2011 Feb 24.
Published in final edited form as: J Agric Food Chem. 2010 Feb 24;58(4):2168–2173. doi: 10.1021/jf903711q

Figure 3. Dose-dependent activation of CAR by flavonoids.

Figure 3

Chrysin, baicalein and galangin were examined for their ability to activate human (A) and mouse (B) CAR in a dose-dependent manner. Significant increase of realative luciferase activity compared to DMSO controls were marked by asterisks (Welch's t-test, P < 0.05, n=3). In contrast to chrysin, which showed maximum CAR activation at 5 μM, baicalein and galangin showed constant increases in CAR response in a dose-dependent manner at 10 μM and below.