Table 3.

Univariate and multivariate Cox model assessing effects of covariates on overall survival

(A) Univariate Cox model
Variable		All stages (n = 280)		Stages I and II (n = 213)
		Hazard ratio	P	Hazard ratio	P
Age		1.044	<0.0001	1.057	<0.0001
Histology	Squamous cell vs. adenocarcinoma	1.585	0.02	1.667	0.03
Tumor^*	T _{2 + 3 + 4} vs. T₁	2.024	0.002	—	—
	T_{2 + 3} vs. T₁	—	—	2.175	0.002
Lymph node^*	N_{1 + 2} vs. N₀	2.122	0.0003	2.531	0.0002
	N₁ vs. N₀	—	—	—	—
Tumor stage^*	II + III + IV vs. I	2.01	0.0005	—	—
	II vs. I	—	—	2.47	0.0002
Fus1 score mean		0.999	0.70	0.999	0.61
Fus1 score level	Low ^† vs. negative ^‡	0.535	0.06	0.502	0.07
	Intermediate ^† vs. negative ^‡	0.744	0.35	0.831	0.60
	High^§ vs. negative^‡	0.685	0.28	0.536	0.13
(B) Multivariate Cox model
Variable		All stages		Stages I and II
		Hazard ratio	P	Hazard ratio	P

Age		1.047	<0.0001	1.059	<0.0001
Histology	Squamous cell vs. adenocarcinoma	1.528	0.04	1.438	0.13
Tumor stage^*	II + III + IV vs. I	2.163	0.0002	—	—
	II vs. I	—	—	2.519	0.0004
Fus1 score level	Low^† vs. negative^‡	0.357	0.002	0.312	0.003
	Intermediate^† vs. negative^‡	0.474	0.02	0.544	0.10
	High^§ vs. negative^‡	0.518	0.06	0.415	0.03

Pathologic tumor, lymph node, and metastasis stage.

^†

Low and intermediate, reduced Fus1 immunohistochemical expression.

^‡

Negative, absence of Fus1 immunohistochemical expression.

^§

High, preserved or normal Fus1 immunohistochemical expression.