Table 3.

Univariate and multivariate Cox model assessing effects of covariates on overall survival

(A) Univariate Cox model
Variable		All stages (n = 280)		Stages I and II (n = 213)
		Hazard ratio	P	Hazard ratio	P
Age		1.044	<0.0001	1.057	<0.0001
Histology	Squamous cell vs. adenocarcinoma	1.585	0.02	1.667	0.03
Tumor*	T 2 + 3 + 4 vs. T1	2.024	0.002	—	—
	T2 + 3 vs. T1	—	—	2.175	0.002
Lymph node*	N1 + 2 vs. N0	2.122	0.0003	2.531	0.0002
	N1 vs. N0	—	—	—	—
Tumor stage*	II + III + IV vs. I	2.01	0.0005	—	—
	II vs. I	—	—	2.47	0.0002
Fus1 score mean		0.999	0.70	0.999	0.61
Fus1 score level	Low † vs. negative ‡	0.535	0.06	0.502	0.07
	Intermediate † vs. negative ‡	0.744	0.35	0.831	0.60
	High§ vs. negative‡	0.685	0.28	0.536	0.13
(B) Multivariate Cox model
Variable		All stages		Stages I and II
		Hazard ratio	P	Hazard ratio	P
Age		1.047	<0.0001	1.059	<0.0001
Histology	Squamous cell vs. adenocarcinoma	1.528	0.04	1.438	0.13
Tumor stage*	II + III + IV vs. I	2.163	0.0002	—	—
	II vs. I	—	—	2.519	0.0004
Fus1 score level	Low† vs. negative‡	0.357	0.002	0.312	0.003
	Intermediate† vs. negative‡	0.474	0.02	0.544	0.10
	High§ vs. negative‡	0.518	0.06	0.415	0.03

^*Pathologic tumor, lymph node, and metastasis stage.

^†Low and intermediate, reduced Fus1 immunohistochemical expression.

^‡Negative, absence of Fus1 immunohistochemical expression.

^§High, preserved or normal Fus1 immunohistochemical expression.