Table 1.
Type of DB[a,l]PDE | Conc., μM | Stable adducts per 14- and 20-kb fragment |
---|---|---|
B11 DNA | ||
(+)-syn-DB[a,l]PDE | 76 | 3 |
(−)-anti-DB[a,l]PDE | 13 | 10 |
B11 cells | ||
(+)-syn-DB[a,l]PDE | 1.4 | 3 |
4.3 | 8 | |
8.5 | 7 | |
(−)-anti-DB[a,l]PDE | 1.4 | 3 |
4.3 | 7 | |
8.5 | 14 | |
MCF-7 cells | ||
DB[a,l]P | 1 | 8 |
2 | 10 |