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Establishment of a juvenile mouse model of late onset anthracycline-mediated cardiotoxicity. A. Mouse pups were injected with saline or doxorubicin (DOX) at 5, 10, 15, and 20 days after birth. B. H & E staining of heart sections prepared from 21 days old mice. C. TUNEL staining of heart sections prepared from 21 days old mice (n=4). D. H & E staining of adult heart sections. E. Electron micrographs of adult hearts from saline and doxorubicin mice.
