FIGURE 2.
Effect of bestrophin and bestrophin mutant overexpression on neurosensory retina function. The effect of bestrophin overexpression on neurosensory retina function was assessed by conventional ERG. Responses to four different flash intensities are superimposed. The major ERG components (a- and b-wave) are labeled. Note that ERGs obtained from the injected eye are similar in waveform to those obtained from the control eye, though with a diminished amplitude. This effect on the ERG was presumably due to the surgery or viral load, because it did not differ with the expression construct (Table 1).