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. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: Dev Biol. 2010 Jan 6;339(2):354–365. doi: 10.1016/j.ydbio.2009.12.033

Figure 1.

Figure 1

Phenotypic variations of Hs2st null kidneys. At e12.5, two different ureteric bud (UB) phenotypes are noted amongst Hs2st−/− embryonic kidneys. The most common phenotype is that of an unbranched UB (approximately two-thirds of kidneys analyzed) and the other is of a UB that has undergone the first dichotomous branching step (T-shaped, approximately one-third). Despite the fact that the UB has branched to a T-shape, overall branching is significantly delayed compared to wild-type and renal agenesis occurs at a 100% penetrance rate.