Table 6.

Antimalarial Activity of Manzamine A and 8-Hydroxymanzamine A by i.p.

Treatments	%parasitemia suppressiona		Survivalb Day of the death (MST)c	Cured
	Day 5	Day 7
Vehicle control			0/5 12/16/12/16/12 (14)	0/5
1 10×3 mg/kg	100	-	0/5 5*/6*/5*/6*/6* 5.6*	0/5
2 10×3 mg/kg	100	100	5/5 (>28)	4/5

^a% Suppression in parasitemia is calculated by considering the mean parasitemia in control group as 100%.

^bnumber of animal survived day 28/total animal in group (the day of the death- post infection).

^cMST- mean survival time (days).

^dNumber of mice without parasitemia (cured) through day 28 post infection.

^*Death related to toxicity